| From | To | Event |
| 1792 | | Dutch Reformed Church congregation founded in Graaff-Reinet. |
| 1792 | | Morovian Mission founded at Genadendal. |
| 1795 | | Xhosa at Prieska |
| 1795 | 1802. | British occupy Cape on behalf of William of Orange. Slaves outnumber European settlers at this time |
| 1795 | | Revolt in Swellendam and Graaff-Reinet. |
| 1796 | | Pieter Pienaar murdered by Jager Afrikaner at Hantam. Afrikaner becomes frontier leader |
| 1798 | | First Post Office. Liquidation of Dutch East India Company. First mosque in southern Africa established in Dorp Street by Tuan Guru. Dutch Reformed Church congregation founded at Swellendam. |
| 1799 | 1802. | Eastern Cape Khoekhoe revolt |
| 1799 | | First London Missionary Society (LMS) station - to |Xam - on Zak River. |
| 1799 | | Fort Frederick built in Algoa Bay by British soldiers. Third Frontier War between the Xhosa and whites. Beginning of London Missionary Society work in South Africa. |
| 1800 | | First printing press in Cape Town. Government Gazette started. |
| 1801 | | Official expedition of Truter; Somerville; Barrow and Daniell; with missionaries Jan Matthys Kok and William Edwards; reaches Dithakong |
| 1801 | | William Anderson established mission at Aakaap and then Klaarwater (later Griquatown) |
| 1801 | | Khoisan spelling book printed by LMS |
| 1803.02 | 1806.01 | Batavian Republic rules the Cape. |
| 1804 | 1806. | Heinrich Lichtenstein travels to Dithakong |
| 1804 | | Uitenhage founded. |
| 1806 | | LMS station at Warmbad; Great Namaqualand |
| 1806 | | First regular inland postal service. |
| 1806 | | Second British occupation of the Cape |
| 1807 | | British ban slave trade, importation of slaves to the Cape ends |
| 1808 | | Clanwilliam founded. |
| 1809 | | Gola's Xhosa community settles at Pramberg. |
| 1809 | | Severe drought in eastern frontier. |
| 1810 | | Montshiwa of Rolong born |
| 1811 | 1812. | William John Burchell travels in the interior |
| 1811 | | Caledon and George founded. Dutch Reformed Church congregation founded in Caledon. Regular circuit courts introduced. |
| 1811 | 1812. | Fourth Frontier War between Xhosa and whites. |
| 1812 | | Molehabangwe of Tlhaping died; succeeded by son Mothibi |
| 1812 | | Cradock and Grahamstown founded. |
| 1813 | | Revd John Campbell conducts mission inspection in the interior |
| 1813 | | Adam Kok's people assert the name Griqua |
| 1813 | | Court proceedings opened to the public. |
| 1814 | | The Cape Colony is formally ceded to Britain. Mail packet service started between Britain and the Cape. |
| 1815 | | Slagter's Nek Rebellion. |
| 1816 | | Missionaries Read and Hamilton; with Hendriks; Kakkerlak and Sedras establish Kuruman Mission (LMS) |
| 1816 | | Wesleyan Mission to Nama at Leliefontein |
| 1817 | | Dutch Reformed Church congregation founded in Uitenhage. |
| 1817 | | Approximately 200 Scottish artisan immigrants brought to Cape by Benjamin Moodie. |
| 1818 | | Dutch Reformed Church congregation founded in Cradock. Settlement of land beyond Orange River. Beaufort West founded. |
| 1818 | 1819. | Fifth Frontier War between Xhosa and whites. Grahamstown attacked. |
| 1819 | | Dutch Reformed Church congregations founded in Beaufort West and Somerset West. |
| 1820 | | James Read produces first book in SeTswana |
| 1820 | | Andries Waterboer elected Griqua Captain at Griquatown |
| 1820 | | Port Elizabeth named by Sir Rufane Donkin. Worcester founded. |
| 1820 | 1821. | Approximately 5000 British settlers arrive in Port Elizabeth as part of the 1820 Settlers immigration scheme, they are settled in the Eastern Cape. |
| 1820 | | George IV |
| 1821 | | Robert Moffat; in Namaqualand from 1817; moves to Kuruman |
| 1822 | 1828. | English becomes the official language of the Cape Colony. |
| 1823.07.01 | | Lewis Broadbent born to the wife of the Methodist missionary Samuel Broadbent at Leeudoringstad, 16km from Wolmaranstad, on the 1st July 1823. Lewis later became a missionary to India. |
| 1823 | | Difaqane (1820s) Battle of Dithakong - MaNthatisi repulsed by Tlhaping with help from Griquas. Tswana to north and east heavily disrupted by Difaqane raids. 1824 Bergenaar rebellion |
| 1823 | | Approximately 146 Irish settlers brought to the Cape by John Ingram. |
| 1824 | | George Thompson travels inland - naming Augrabies Falls "Cataract of King George" |
| 1824 | | Construction of road through Fransch Hoek Pass. First Synod of the Dutch Reformed Church. Mission station at Lovedale founded. First lighthouse opened. |
| 1825 | | Dutch Reformed Church congregation founded in Somerset East. |
| 1825 | | First steamship in Table Bay. Depreciated rix dollar converted into British sterling. The Anglican St. Mary's Collegiate Church started in Port Elizabeth. The Jubilee Park Cemetery in Uitenhage in use circa 1825. |
| 1826 | | Adam Kok II establishes Philippolis Griqua Captaincy |
| 1826 | | Dutch Reformed Church congregations founded in Clanwilliam, Colesberg, Durbanville and Tijgerberg. |
| 1828 | | Ordinance 50 repeals pass laws |
| 1828 | | Circa 1828, the Union Chapel (London Missionary Society - i.e. Congregational) in Port Elizabeth is founded, records start in 1831. St. Mary's Cemetery started in Port Elizabeth circa 1828. |
| 1830 | | Moffat's printing press transported to Kuruman by ox wagon |
| 1830 | | Full civil privileges granted to Roman Catholics in the Cape. Colesberg founded. Road over Sir Lowry's Pass opened. |
| 1830 | | William IV |
| 1831 | | Dutch Reformed Church congregation founded in Albany. First publication of De Zuid Afrikaan (ons Land). First issue of Grahamstown Journal. |
| 1833 | | Dutch Reformed Church parish in Piquetberg (Piketberg) founded. |
| 1833 | 1839. | Approximately 750 juveniles brought to the Cape as apprentices. |
| 1834.12.21 | 1835.09 | Sixth Frontier War between Xhosa and whites. |
| 1834 | | Abolition of legal slavery; but slaves apprenticed for four years |
| 1834 | 1835. | Andrew Smith with artist Charles Davidson Bell travels in the interior |
| 1834 | | Berlin Mission Society establishes station at Bethulie; and out-station among Korana at Pniel in 1845. |
| 1834 | | The Anglican St. John's Church is built in Bathurst, but its burial records go back to 1823. King William's Town founded. Slaves officially freed but apprenticed for next 4 years. |
| 1834 | | Kommissie treks from Cape begins. Port Natal renamed Durban. |
| 1835 | 1836. | Louis Trichardt, Hans van Rensburg and Andries Potgieter trek north. |
| 1835 | | Halley's Comet |
| 1836 | | James Alexander travels through Namaqualand |
| 1836 | | The Great Trek has reached the Transvaal and the Free State areas. |
| 1836 | | Potgieter's trekkers defeat Ndebele at the Battle of Vegkop. |
| 1837 | | Piet Retief publishes his "Manifesto". |
| 1837 | | Andries Potgieter and Piet Uys, helped by Rolong and Griqua tribes, defeat Ndebele at Mosega. Louis Trichardt arrives in Lourenco Marques. Seperate administrative districts granted to Port Elizabeth, Cradock and Colesburg. |
| 1837 | | Victoria |
| 1838.02 | | Piet Retief and his people are murdered by Dingaan's soldiers at Dingaan's kraal and Weenen. |
| 1838.12.16 | | Battle of Blood River fought between Zulus and Boers. |
| 1838 | | Russell Road (Hyman's Kloof) Cemetery established in Port Elizabeth. Pietermaritzburg founded in 1838. Boers found Republic of Natal. |
| 1839 | | Dutch Reformed Church parishes founded in Bredasdorp and Riversdale. Potchefstroom founded. |
| 1840 | 1849. | Expansion of commercial wool farmers in Karoo transforms colonial economy. Pedi migrate to work on Cape farms |
| 1840 | | The Anglican St. Katherine's Church is founded in Uitenhage. |
| 1841 | | Missionary David Livingstone arrives in South Africa - proceeds to Kuruman before journeying through Central Africa |
| 1841 | | Circa 1841, the Methodist Church founded in Port Elizabeth. Trekkers council set up in Potchefstroom. |
| 1842 | | Dutch Reformed Church parish founded in Prince Albert. Dick King's ride from Durban to Grahamstown. |
| 1842 | 1843. | War between the British and the Boers in Natal. |
